ARTICLE

HEALTH

 NIGELLA SATIVA ALLEVIATES BONE CANCER

January 4, 2021 - Dr. Muhammad Muhktar

Nigella sativa is also known as black cumin, black seed, kalonji and haba al barakah.  It is not also knows as black caraway as some sites states.  There are more than 1000 peer reviews and as stated by our beloved Prophet Mohammad, PBUH, this seed should be used often as a cure for all disease,except death.

WRITTEN BY DR. MUHAMMAD MUHKTAR, GOOGLE NOTED SCHOLAR 

​What is Bone Cancer?

It is a fact that any cells in the human body can get out of control and starts its abnormal growth, known as cancer.
Human bones supporting the body's overall framework and shape comprise two types of cells known as 1) Osteoblast – the cells forming new bones and 2) Osteoclast – cells capable of dissolving old bones. Usually, bone cancers are known as sarcomas having several types and subtypes. The naming of bone cancer is based on the part of the bone involved and tissues surrounding cancerous bones.

Important to mention here is bone marrow cancer. This cancer is mainly in the bones' spongy tissues known as marrow, which is present inside the bones.
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Bone metastases are the complex type of cancer that affects bones originating from other cells and spreading to bones. Prominent are breast, prostate, and lung cancer that cause bone metastases.

Traditional Remedy for Bone Cancer and Bone Metastases

Black seed (Nigella sativa) since time immemorial is considered a treatment for several types of ailments, including cancers. Recent scientific studies strongly suggest the efficacy and effectiveness in providing a curative effect for bone cancer.

1. Thymoquinone, an Ingredient of the Nigella sativa Oil Inhibit Bone Metastasis – As discussed above, bone metastasis is the invasion of other types of cancer into bones. For example, breast cancer spreads to the bone marrow of various bones in the human body, particularly femora, tibiae, and mandibular bones.  A scientific study evaluated the effect of Thymoquinone – an ingredient mainly found in the oily fraction of the Nigella sativa. It was observed that Thymoquinone could inhibit bone cancer resulting from tumor metastasis due to breast cancer. Important to mention here is this study also identified that black seed oil components stop the production of chemokine receptor type 4 (CXCR4), supposed to be involved in bone metastasis.

 
This is quite intriguing proof of concept explaining the underlying reason also that how Nigella sativa control bone cancer.
It is essential to mention here that thymoquinone has been reported to inhibit cancer cell growth and the vascularization system fulfilling these cells' nutritional requirements.

This involves various signaling cascades reported to be activated by the thymoquinone fraction of the Nigella sativa. Overall, multiple pathways are involved in suppressing bone cancer by the Nigella sativa and its preparations (1, 2).
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1. Complete Remission of Severe Bone Marrow Hypoplasia with Black Cumin (Nigella sativa) Ingestion – A case report from the Ankara University, Faculty of Medicine provides compelling evidence about the role of Nigella sativa regular ingestion controlling Severe Bone Marrow Hypoplasia in a patient who has T-cell acute lymphoblastic leukemia. A well-designed evaluation of various cancerous tissue and cells involved in the oncogenesis revealed that Nigella sativa intake for two months led to a severe decrease in cancerous tissues and reverted toward normal cellular functions. Encouraged by the findings, scientists involved in this study have urged the US Food and Drug Administration to investigate the benefits of Nigella sativa in bone cancer already coined "generally recognized as safe" by this drug regulatory authority (3).
2. Anti-cancer Properties of Nigella sativa, including Bone Cancer (Sarcomas) – There is a wealth of scientific literature supporting the anti-cancer effects of Nigella sativa in various cancer types. As we know, cancer is the abnormal growth (proliferation) of cells. The anti-proliferative effects of Nigella sativa are quite beneficial in sarcoma. An extensive review article suggests Nigella sativa seeds and their oils both have an anti-cancer effect. However, the high-quality Nigella sativa oil effect is much better in inhibiting the growth of cancerous cells (4).
3. Black Seed Oil Inhibits Bone Cancer and Support Healthy Bone Marrow Cells – An intriguing aspect of Nigella oil is not only controlling abnormal growth of cancer cells, but instead, it also promotes the development of normal bone marrow cells. A study entitled “Nigella sativa (black seed) is an effective herbal remedy for every disease except death – a Prophetic statement which modern scientists confirm unanimously: A review” describes that based on existing information, Nigella oil is supposed to enhance the growth of bone marrow by 250%. Sometimes anti-cancer medications have associated toxicities. However, this aspect of Nigella helps exert further healthy bone formation – a much-needed requirement for people who have bone cancer (5).

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Usage of Nigella sativa for bone cancer

The above scientific studies strongly suggest the beneficial role of Nigella sativa in treating cancer. The anti-proliferative effect of Nigella has been proved through several studies. However, the rejuvenation and regeneration of healthy bones is an important aspect. As the bones are relatively hardy tissue and preparations like Nigella promoting healthy bones make it the choice remedy for bone cancer and general bone strength. However, it is essential to keep in mind the relative differential benefits of its preparation: crude formulation of Nigella sativa oil.

Dosage
As discussed in the above scientific papers, both crude and Nigella oil are efficacious for bone cancer. However, one of the above studies also alludes to the better advantage of the Nigella oil. It is essential to keep in mind the severity of cancer and your body's capability to assimilate one of the preparations. However, Nigella oil yields better outcomes.

Directions for Usage
People who have bone cancer should take three teaspoonsful of Nigella sativa oil with an equal volume of honey for better results. Even if the honey is not available, people are advised to take Nigella oil individually. 

As described in the science section above that Nigella crude fraction (seeds) are also useful. Once you feel that enough remission has taken place, it is advisable to continue taking a teaspoonful of Nigella sativa for 2 – 3 months for overall cancer relief.

It is pertinent to mention here that the quality of the oil plays a significant role. Lower quality or oil not extracted through proper pressing may not be so useful.

References
1.         Shanmugam MK, Ahn KS, Hsu A, Woo CC, Yuan Y, Tan KHB, et al. Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis. Front Pharmacol. 2018;9:1294. https://pubmed.ncbi.nlm.nih.gov/30564115/
2.         Majdalawieh AF, Fayyad MW, Nasrallah GK. Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa. Crit Rev Food Sci Nutr. 2017;57(18):3911-28.
https://www.tandfonline.com/doi/full/10.1080/10408398.2016.1277971
3.         Narli Ozdemir Z, Ozturk C, Kuzu I, Ozcan M. Severe Bone Marrow Hypoplasia with Black Cumin (Nigella sativa) Ingestion in a Patient with T-ALL in First Complete Remission. Turk J Haematol. 2019;36(3):215-7.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682787/
4.         Majdalawieh AF, Fayyad MW. Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive. J Ayurveda Integr Med. 2016;7(3):173-80. https://pubmed.ncbi.nlm.nih.gov/27649635/
5.         Hussain DAS, Hussain MM. Nigella sativa (black seed) is an effective herbal remedy for every disease except death – a Prophetic statement which modern scientists confirm unanimously: A review. Advancement in Medicinal Plant Research. 2016;4(2):27-57. http://www.netjournals.org/z_AMPR_16_008.html