NIGELLA SATIVA - BLACK SEEDS

REsources

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1. Qidwai W, et al Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial . J Altern Complement Med. (2009)
   
2. The medicinal potential of black seed (Nigella sativa) and its components
3. Ahmad A, et al A review on therapeutic potential of Nigella sativa: A miracle herb . Asian Pac J Trop Biomed. (2013)
4. Ali BH, Blunden G Pharmacological and toxicological properties of Nigella sativa . Phytother Res. (2003)
5. Işik H, et al Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients . Med Princ Pract. (2010)
6. Salem ML Immunomodulatory and therapeutic properties of the Nigella sativa L. seed . Int Immunopharmacol. (2005)
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8. Chemical composition and microflora of black cumin (Nigella sativa L.) seeds growing in Saudi Arabia
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11. Novel lipid constituents identified in seeds of Nigella sativa (Linn)
12. Nutritional profile of indigenous cultivar of black cumin seeds and antioxidant potential of its fixed and essential oil
13. Chemical composition of Nigella sativa L. seeds
14. Keyhanmanesh R, et al The main relaxant constituents of nigella sativa methanolic fraction on Guinea pig tracheal chains . Iran J Allergy Asthma Immunol. (2013)
15. Nigellidine — A new indazole alkaloid from the seeds of Nigella sativa
16. Ali Z, et al Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa . J Nat Prod. (2008)
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19. Mehta BK, Pandit V, Gupta M New principles from seeds of Nigella sativa . Nat Prod Res. (2009)
20. Quantification and diversity in the black seeds (Nigella sativa L.): Gene stock of Pakistan for their composition of mineral nutrients
21. el Tahir KE, Ashour MM, al-Harbi MM The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action . Gen Pharmacol. (1993)
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25. STUDIES ON THE CHEMICAL CONSTITUTION OF EGYPTIAN NIGELLA SATIVA L. SEEDS. II1) THE ESSENTIAL OIL
26. Antibacterial Activity of Thymoquinone and Thymohydroquinone of Nigella sativa L. and Their Interaction with Some Antibiotics
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56. Al-Ghamdi MS The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa . J Ethnopharmacol. (2001)
57. Bin Sayeed MS, et al The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers . J Ethnopharmacol. (2013)
58. Akhtar M, et al Neuroprotective effects of chloroform and petroleum ether extracts of Nigella sativa seeds in stroke model of rat . J Pharm Bioallied Sci. (2013)
59. Hosseinzadeh H, et al Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats . Med Sci Monit. (2005)
60. Akhondian J, et al The effect of thymoquinone on intractable pediatric seizures (pilot study) . Epilepsy Res. (2011)
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67. Hosseini M, et al The effects of Nigella sativa hydro-alcoholic extract and thymoquinone on lipopolysaccharide - induced depression like behavior in rats . J Pharm Bioallied Sci. (2012)
68. Bin Sayeed MS1, et al Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males . J Ethnopharmacol. (2014)
69. Nigella sativa Oil Enhances the Spatial Working Memory Performance of Rats on a Radial Arm Maze
70. Seif AA Nigella sativa attenuates myocardial ischemic reperfusion injury in rats . J Physiol Biochem. (2013)
71. Dehkordi FR, Kamkhah AF Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension . Fundam Clin Pharmacol. (2008)
72. Datau EA, et al Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male . Acta Med Indones. (2010)
73. Sabzghabaee AM, et al Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial . Med Arh. (2012)
74. Bamosa AO, et al Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus . Indian J Physiol Pharmacol. (2010)
75. Najmi A, et al Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome . Int J Diabetes Dev Ctries. (2008)
76. Hamed A, Alobaidi A Effect of Nigella Sativa and Allium Sativum Coadminstered with Simvastatin in Dyslipidemia Patients: A Prospective, Randomized, Double-blind Trial . Antiinflamm Antiallergy Agents Med Chem. (2013)
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78. Woollard KJ Immunological aspects of atherosclerosis . Clin Sci (Lond). (2013)
79. Mahmood MS, et al The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production . Phytother Res. (2003)
80. Mat MC, Mohamed AS, Hamid SS Primary human monocyte differentiation regulated by Nigella sativa pressed oil . Lipids Health Dis. (2011)
81. El-Dakhakhny M, et al The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions . Planta Med. (2002)
82. Rchid H, et al Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets . Fundam Clin Pharmacol. (2004)
83. Kanter M, et al Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats . Tohoku J Exp Med. (2003)
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88. Tripathi YB, Chaturvedi AP, Pandey N Effect of Nigella sativa seeds extracts on iNOS through antioxidant potential only: crude/total extract as molecular therapy drug . Indian J Exp Biol. (2012)
89. Haq A, et al Nigella sativa: effect on human lymphocytes and polymorphonuclear leukocyte phagocytic activity . Immunopharmacology. (1995)
90. Majdalawieh AF, Hmaidan R, Carr RI Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity . J Ethnopharmacol. (2010)
91. Anti-asthmatic and Anti-allergic Effects of Thymoquinone on Experimentally- Induced Hypersensitivity
92. Nikakhlagh S, et al Herbal treatment of allergic rhinitis: the use of Nigella sativa . Am J Otolaryngol. (2011)
93. Kalus U, et al Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases . Phytother Res. (2003)
94. Boskabady MH, et al The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients . Fundam Clin Pharmacol. (2007)
95. Chehl N, et al Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells . HPB (Oxford). (2009)
96. Gheita TA, Kenawy SA Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study . Phytother Res. (2012)
97. Observations on the Biological Effects of Black Cumin Seed (Nigella sativa) and Green Tea (Camellia sinensis)
98. Salem ML, Hossain MS Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection . Int J Immunopharmacol. (2000)
99. Barakat EM, El Wakeel LM, Hagag RS Effects of Nigella sativa on outcome of hepatitis C in Egypt . World J Gastroenterol. (2013)
100. Effects of Oral Administration of Water Extract of Nigella sativa on the Hypothalamus Pituitary Adrenal Axis in Experimental Diabetes
101. Mansour SW, et al Sensibility of male rats fertility against olive oil, Nigella sativa oil and pomegranate extract . Asian Pac J Trop Biomed. (2013)
102. Boskabady MH, Keyhanmanesh R, Saadatloo MA Relaxant effects of different fractions from Nigella sativa L. on guinea pig tracheal chains and its possible mechanism(s) . Indian J Exp Biol. (2008)
103. The Contribution of Water and Lipid Soluble Substances in the Relaxant Effects of Nigella sativa Extract on Guinea Pig Tracheal Smooth Muscle (in vitro)
104. Boskabady MH, et al Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig . BMC Pharmacol. (2004)
105. el Tahir KE, Ashour MM, al-Harbi MM The respiratory effects of the volatile oil of the black seed (Nigella sativa) in guinea-pigs: elucidation of the mechanism(s) of action . Gen Pharmacol. (1993)
106. Boskabady MH, Farhadi J The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial . J Altern Complement Med. (2008)
107. Toppozada HH, Mazloum HA, el-Dakhakhny M The antibacterial properties of the Nigella sativa l. seeds. Active principle with some clinical applications . J Egypt Med Assoc. (1965)
108. Hanafy MS, Hatem ME Studies on the antimicrobial activity of Nigella sativa seed (black cumin) . J Ethnopharmacol. (1991)
109. Morsi NM Antimicrobial effect of crude extracts of Nigella sativa on multiple antibiotics-resistant bacteria . Acta Microbiol Pol. (2000)
110. O'Mahony R, et al Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori . World J Gastroenterol. (2005)
111. Salem EM, et al Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia . Saudi J Gastroenterol. (2010)
112. Gerrits MM, et al Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implications . Lancet Infect Dis. (2006)
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116. Hadjzadeh MA, et al The preventive effect of N-butanol fraction of Nigella sativa on ethylene glycol-induced kidney calculi in rats . Pharmacogn Mag. (2011)
117. Hadjzadeh MA, et al Ethanolic extract of nigella sativa L seeds on ethylene glycol-induced kidney calculi in rats . Urol J. (2007)
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122. Fujioka S, et al Function of nuclear factor kappaB in pancreatic cancer metastasis . Clin Cancer Res. (2003)
123. Abdel-Hamid NM, et al Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma . Environ Health Prev Med. (2013)
124. Ng WK, Yazan LS, Ismail M Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein . Toxicol In Vitro. (2011)
125. Hasan TN, et al Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis . Nat Prod Commun. (2013)
126. Cytotoxicity of thymoquinone (TQ) from Nigella sativa towards human cervical carcinoma cells (HeLa)
127. Al-Ali A, et al Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats . J Ayub Med Coll Abbottabad. (2008)
128. Sabzghabaee AM, et al Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial . Med Arh. (2012)
129. Gheita TA, Kenawy SA Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study . Phytother Res. (2012)
130. Bamosa AO, et al Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus . Indian J Physiol Pharmacol. (2010)
131. Nikakhlagh S, et al Herbal treatment of allergic rhinitis: the use of Nigella sativa . Am J Otolaryngol. (2011)
132. Kalus U, et al Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases . Phytother Res. (2003)
133. Najmi A, et al Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome . Int J Diabetes Dev Ctries. (2008)
134. Işik H, et al Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients . Med Princ Pract. (2010)
135. Akhondian J, et al The effect of thymoquinone on intractable pediatric seizures (pilot study) . Epilepsy Res. (2011)
136. Qidwai W, et al Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial . J Altern Complement Med. (2009)
137. Dehkordi FR, Kamkhah AF Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension . Fundam Clin Pharmacol. (2008)
138. Boskabady MH, et al The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients . Fundam Clin Pharmacol. (2007)
139. Boskabady MH, Farhadi J The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial . J Altern Complement Med. (2008)
140. Datau EA, et al Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male . Acta Med Indones. (2010)
141. Barakat EM, El Wakeel LM, Hagag RS Effects of Nigella sativa on outcome of hepatitis C in Egypt . World J Gastroenterol. (2013)
142. Bin Sayeed MS, et al The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers . J Ethnopharmacol. (2013)
143. Mariam A. Abu- Al-Basal , 2011. Influence of Nigella sativa Fixed Oil on Some Blood Parameters and Histopathology of Skin in Staphylococcal-Infected BALB/c Mice.Pakistan Journal of Biological Sciences,14: 1038-1046.
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 "Thymoquinone Induces Cell Death in Human Squamous Carcinoma Cells via Caspase Activation-Dependent Apoptosis and LC3-II Activation-Dependent Autophagy"

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Black Cumin Benefits:
Harvard EDU Study "The cancer research group concluded that when a person has a healthy immune system, most cancers published here cells are destroyed before most cancers can pose a risk to a person's health."

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