Overview of Non-Hodgin’s Disease
Lymphoma is a broader term used for cancer originating from the lymphatic system. Lymphocyte, a subset of white blood cells is a vital part of the immune system. Lymphocytes play a crucial role against infectious diseases by germ-fighting mechanism. 
t has been estimated that 3% of all cancer incidences across the globe is lymphoma is a type of cancer. Certain hereditary disorders, immunosuppressive medications, and certain viruses are considerable risk factors for lymphoma because of immune system damage. 
The abnormal growth of Lymphocytes can cause tumor formation. The metastatic nature of the tumor generates Non-Hodgkin's lymphoma. Non-Hodgkin's lymphoma treatment prognosis depends upon multiple factors, such as definite subtype of lymphocyte, precise diagnosis, early intervention, and treatment choice. 
B-cells and T-cells are the two types of lymphocyte from where Non-Hodgkin's lymphoma mostly starts. B cells produce antibodies to fight against infectious causing germs. B cells type of Non-Hodgkin's lymphoma includes diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and Burkitt lymphoma.
T cells lymphocytes can kill foreign invaders directly.
Non-Hodgkin's lymphoma occurs much less often in T cells. Subtypes of non-Hodgkin's lymphoma that involve T cells are less common than B cells type of Non-Hodgkin's lymphoma. T cells type of Non-Hodgkin's lymphoma includes peripheral T-cell lymphoma and cutaneous T-cell lymphoma.
Cancerous lymphocytes involved in Non-Hodgkin's lymphoma are not only restricted to the lymph nodes can but can also spread to other parts of the lymphatic system, such as lymphatic vessels, tonsils, adenoids, spleen, thymus, and bone marrow.
Occasionally, non-Hodgkin's lymphoma can spread to other organs that are not involved in the lymphatic system. 
Non-Hodgkin's lymphoma associated signs and symptoms are:
· Enlarged lymph nodes in neck, armpits, or groin
· Pain or swelling in the abdomen
· Chest pain, breathing difficulty, or frequent coughing
· Consistent fatigue
· Nocturnal perspiration
· Unexplained weight loss 
Nigella Sativa effective for Non-Hodgkin’s Lymphoma Treatment
Several conventional therapies that are used for Non-Hodgkin’s Lymphoma treatment include chemotherapy, radiation therapy, engineering immune cells to fight lymphoma, bone marrow transplant, immunotherapy, and targeted drug therapy. But these conventional therapies have different side effects. 
Complementary and alternative medicine is used along with standard medical care to help manage symptoms and side effects from cancer and its treatment. 
The use of complementary and alternative medicine among lymphoma survivors is widespread. Complementary and alternative medicine use is imperious to provide safe, effective, and comprehensive cancer care throughout the spectrum of treatment and survivorship. 
Therefore, many research studies are conducted to find out the efficacy of Nigella sativa as complementary and alternative medicine to treat Non-Hodgkin’s Lymphoma. Nigella sativa and its herbal formulations can also be used as dietary supplements to boost immune system functioning and support Non-Hodgkin’s Lymphoma treatment.
What phytochemicals of Nigella sativa are responsible for anti-cancer properties?
Nigella sativa cures cancer because of its unique phytochemical constituents. Thymoquinone, the principal bioactive phytochemicals present in Nigella sativa plays a potential role against Non-Hodgkin’s Lymphoma. Nigella sativa has anti-proliferative, pro-apoptotic, anti-oxidant, anti-oxidant, anti-mutagenic, anti-angiogenic, and antimetastatic effects.
Nigella sativa is also a rich source of other phytochemicals such as thymol, thymohydroquinone, dithymoquinone, nigellimine-N-oxide, nigellicine, nigellidine, and carvacrol. These phytochemicals also have cytotoxic and anti-cancer activity. Combination of all these phytochemicals present in Nigella sativa exerts anticancer functioning against Non-Hodgkin’s Lymphoma. 
NIGELLA SATIVA NON HODGKINS
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How does Nigella sativa act against Non-Hodgkin’s Lymphoma?
Different therapeutic properties of Nigella sativa acts against Non-Hodgkin’s Lymphoma development and progression:
Anti-proliferative and pro-apoptotic effect
Laboratory test results reported that Nigella sativa could alter cancer morphology by shrinking the cellular size. Nigella sativa is also inducing DNA damage. Both of these mechanisms lead to cell death. Nigella sativa can reduce cell proliferation and thus halts cancer proliferation. 
Nigella sativa extract causes genomic DNA fragmentation and induces apoptosis by triggering p53 in mitochondria to activate proapoptotic proteins.
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Subsequently, cytochrome c is released from mitochondria and the caspase cascade is activated. In this way, apoptosis is induced.
The apoptotic effect of Nigella sativa specifically tested for lymphoma and showed p53 induced mitochondria-mediated apoptosis. 
Researchers expected that using of Nigella sativa essential oil could provide synergistic benefit with conventional treatment for lymphoma.
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