Black Seed/Black Seed Oil Healing Effect on Sarcoidosis
WRITTEN BY DR. MUHAMMAD MUHKTAR, NOTED GOOGLE SCHOLAR AND PHD
THIS ARTICLE IS COPYWRITTEN FOR NIGELLASATIVACENTER.COM ONLY. ALL RIGHTS RESERVED.
PLEASE NOTE WE HAVE RECOMMENDED SOME AFFILIATE PRODUCTS BELOW. WE MAY GET A SMALL COMMISSION IF YOU PURCHASE. PLEASE CHECK OUT OUR PRIVACY POLICY WHEN IN DOUBT.
THIS ARTICLE IS COPYWRITTEN FOR NIGELLASATIVACENTER.COM ONLY. ALL RIGHTS RESERVED.
PLEASE NOTE WE HAVE RECOMMENDED SOME AFFILIATE PRODUCTS BELOW. WE MAY GET A SMALL COMMISSION IF YOU PURCHASE. PLEASE CHECK OUT OUR PRIVACY POLICY WHEN IN DOUBT.
Based on my scientific evaluations, Nigella oil in Sarcoidosis (Pulmonary) will be a miraculous treatment. This has been ignored in the past by researchers also. Dr. Muhammad Muhktar, Noted Google Scholar
Introduction
Sarcoidosis is an inflammatory disorder mainly affecting the lungs and lymph glands. The disease has characteristic features of abnormal nodular structure (known as granulomas) associated with inflamed tissue hampering the organ's normal physiological function.
There are several manifestations of sarcoidosis; however, the prevalence of pulmonary sarcoidosis is very high. People suffering from pulmonary sarcoidosis have troubles with their respiratory function. T
he exact cause of this type of sarcoidosis is unknown; however, it is characterized as an autoimmune disease having a disruptive immune system. Potential therapeutic inventions are either ameliorating faulty immune hyperactivity or treating patients with immunosuppressants to overcome autoimmune reactions dangerous to organs like lungs. As of now, there is no specific treatment for pulmonary or other types of sarcoidosis.
Sarcoidosis is an inflammatory disorder mainly affecting the lungs and lymph glands. The disease has characteristic features of abnormal nodular structure (known as granulomas) associated with inflamed tissue hampering the organ's normal physiological function.
There are several manifestations of sarcoidosis; however, the prevalence of pulmonary sarcoidosis is very high. People suffering from pulmonary sarcoidosis have troubles with their respiratory function. T
he exact cause of this type of sarcoidosis is unknown; however, it is characterized as an autoimmune disease having a disruptive immune system. Potential therapeutic inventions are either ameliorating faulty immune hyperactivity or treating patients with immunosuppressants to overcome autoimmune reactions dangerous to organs like lungs. As of now, there is no specific treatment for pulmonary or other types of sarcoidosis.
Nigella sativa (black seed) comprises many beneficial ingredients exerting both immunomodulatory and anti-inflammatory effects. Notably, a recent article describes the benefits of Nigella seeds and its oil preparation in various autoimmune disorders (1). Based on the existing wealth of information, it sounds very plausible to characterize Nigella sativa seeds and oil formulations potentials in sarcoidosis management. Empirical knowledge strongly suggests that sarcoidosis can be potentially treated with harmless immune-boosting black seed formulations(2).
This article mainly described the sarcoidosis disease aspects and relevant scientific information, proving that black seed is a choice remedy for this disease.
This article mainly described the sarcoidosis disease aspects and relevant scientific information, proving that black seed is a choice remedy for this disease.
General Information about Sarcoidosis
As mentioned above the sarcoidosis is a disease characterized by small groups of inflammatory cells in any part of the body. However, the primary targets are the lungs and lymph nodes. These small collections of cells are characterized as granulomas by healthcare professionals. Besides lungs, other parts of the body having granulomas are eyes, heart, skins, and infrequently others. Unfortunately, there is no approved drug for curing sarcoidosis. It has been reported that almost 90% of sarcoidosis patients suffer from pulmonary sarcoidosis in which lungs are the primary organ having granulomas.
The underlying cause of sarcoidosis is still an active area of investigation; however, it is perceived that the faulty immune system led to autoimmune disorders. Patients are mainly prescribed immunosuppressants.
Notably, during the COVID-19 pandemic, it has been realized that immunosuppressants being given to sarcoidosis patients make them vulnerable to abnormal outcomes(3). There is a need for natural remedies with immunomodulatory characteristics like thymoquinone present in the oily fraction of black seeds (2, 4).
As mentioned above the sarcoidosis is a disease characterized by small groups of inflammatory cells in any part of the body. However, the primary targets are the lungs and lymph nodes. These small collections of cells are characterized as granulomas by healthcare professionals. Besides lungs, other parts of the body having granulomas are eyes, heart, skins, and infrequently others. Unfortunately, there is no approved drug for curing sarcoidosis. It has been reported that almost 90% of sarcoidosis patients suffer from pulmonary sarcoidosis in which lungs are the primary organ having granulomas.
The underlying cause of sarcoidosis is still an active area of investigation; however, it is perceived that the faulty immune system led to autoimmune disorders. Patients are mainly prescribed immunosuppressants.
Notably, during the COVID-19 pandemic, it has been realized that immunosuppressants being given to sarcoidosis patients make them vulnerable to abnormal outcomes(3). There is a need for natural remedies with immunomodulatory characteristics like thymoquinone present in the oily fraction of black seeds (2, 4).
Why Black Seed Oil Could be the Best Option for Treating Sarcoidosis
Based on the current scientific information, T lymphocytes' role, mainly the CD4 positive effector T- cell population, has been described in the pathogenesis of sarcoidosis. This involves an intricate web of cytokines and other inflammatory molecular, leading to the granulomatous situation among sarcoidosis patients (5). A US patent no US7592327B2 strongly suggests that a pure form of Nigella sativa seeds has the potential to alleviate T-cells abnormalities, mainly observed in a similar situation, particularly asthma/allergy (6).
This particular patent also specifically mention the usage of Nigella sativa for the treatment of sarcoidosis as “Th1 cells develop in the presence of a large range of antigens associated with delayed hypersensitivity response like tuberculosis, sarcoidosis, leprosy, and viruses, generates predominantly IFN gamma which inhibits the differentiation and production of cytokines by Th2 and vice versa." As such convincing evidence exists, and now in the era of COVID-19, particularly patients suffering from pulmonary sarcoidosis can benefit greatly.
Almost 90% of patients suffering from sarcoidosis have inflammatory lungs due to granulomatous conditions. This is associated with airways' abnormalities, mainly the tracheal responsiveness (TR) during respiration and lung inflammation. A scientific study showed that Nigella sativa oil normalizes TR; instead, it reduces lung inflammation even due to toxic elements like sulfur mustard (7). This is a clear indication that it is mainly the oily fraction of the Nigella sativa exhibiting anti-inflammatory and beneficial effects. The Nigella sativa seed and its oil can be consumed by the patients suffering from sarcoidosis to overcome their disease symptoms.
Besides the above-described study, several scientific reports have provided convincing evidence that Nigella sativa ameliorates injuries to lungs via inhibiting inflammatory responses either because of any infection or injury.
In discussing pulmonary sarcoidosis, the formation of small granuloma in the lungs is followed by an inflammatory cascade. These are manifested in the form of bronchial inflammatory cells infiltration, oedema of the alveolar region, interstitial fibrosis, the emergence of macrophages, ultimately leading to necrosis or damaged tissues of lungs.
This condition hampers proper respiration and creates pathologies like difficulty in breathing, lesser oxygen distribution to almost every part of the body due to lesser oxygenation of blood via inhalation. Fortunately, thymoquinone present in Nigella has anti-inflammatory, immunomodulatory, and prevents lung injury during sarcoidosis.
Besides all the above is robust scientific proof; in Islamic medicine, Nigella sativa is considered the most vital medications for almost every ailment except death. People have used its preparation since antiquity to overcome various conditions, and treating sarcoidosis with Nigella seeds or its oil is the most plausible. Importantly, there is no approved medication by any of the drug regulatory authorities globally, making this useful product for rejuvenating the body strength and overcoming sarcoidosis symptoms.
Based on the current scientific information, T lymphocytes' role, mainly the CD4 positive effector T- cell population, has been described in the pathogenesis of sarcoidosis. This involves an intricate web of cytokines and other inflammatory molecular, leading to the granulomatous situation among sarcoidosis patients (5). A US patent no US7592327B2 strongly suggests that a pure form of Nigella sativa seeds has the potential to alleviate T-cells abnormalities, mainly observed in a similar situation, particularly asthma/allergy (6).
This particular patent also specifically mention the usage of Nigella sativa for the treatment of sarcoidosis as “Th1 cells develop in the presence of a large range of antigens associated with delayed hypersensitivity response like tuberculosis, sarcoidosis, leprosy, and viruses, generates predominantly IFN gamma which inhibits the differentiation and production of cytokines by Th2 and vice versa." As such convincing evidence exists, and now in the era of COVID-19, particularly patients suffering from pulmonary sarcoidosis can benefit greatly.
Almost 90% of patients suffering from sarcoidosis have inflammatory lungs due to granulomatous conditions. This is associated with airways' abnormalities, mainly the tracheal responsiveness (TR) during respiration and lung inflammation. A scientific study showed that Nigella sativa oil normalizes TR; instead, it reduces lung inflammation even due to toxic elements like sulfur mustard (7). This is a clear indication that it is mainly the oily fraction of the Nigella sativa exhibiting anti-inflammatory and beneficial effects. The Nigella sativa seed and its oil can be consumed by the patients suffering from sarcoidosis to overcome their disease symptoms.
Besides the above-described study, several scientific reports have provided convincing evidence that Nigella sativa ameliorates injuries to lungs via inhibiting inflammatory responses either because of any infection or injury.
In discussing pulmonary sarcoidosis, the formation of small granuloma in the lungs is followed by an inflammatory cascade. These are manifested in the form of bronchial inflammatory cells infiltration, oedema of the alveolar region, interstitial fibrosis, the emergence of macrophages, ultimately leading to necrosis or damaged tissues of lungs.
This condition hampers proper respiration and creates pathologies like difficulty in breathing, lesser oxygen distribution to almost every part of the body due to lesser oxygenation of blood via inhalation. Fortunately, thymoquinone present in Nigella has anti-inflammatory, immunomodulatory, and prevents lung injury during sarcoidosis.
Besides all the above is robust scientific proof; in Islamic medicine, Nigella sativa is considered the most vital medications for almost every ailment except death. People have used its preparation since antiquity to overcome various conditions, and treating sarcoidosis with Nigella seeds or its oil is the most plausible. Importantly, there is no approved medication by any of the drug regulatory authorities globally, making this useful product for rejuvenating the body strength and overcoming sarcoidosis symptoms.
Dosage of Black Seed Preparations for the Treatment of Sarcoidosis
The US patent US7592327B2 allude that Nigella sativa purified formulation is beneficial for pulmonary sarcoidosis and several other ailments resembling pathologies with this disease. Based on this strong proof of concept, the recommended dosage is a half teaspoonful of black cumin oil with one teaspoon of honey regularly. The dosage may be increased up to one teaspoon depending on the patient's conditions.
Scientific studies provide essential information that anti-inflammatory and immunoregulatory components are in the oily part of the black seed oil. We recommend perfect press black seed oil one teaspoonful with an equal volume of tea or coffee based on this trustworthy information.
For getting better results, initially take ½ teaspoon of Nigella sativa with the same volume of honey in the first week, followed by the above-described dose. This treatment regimen has a logical background. Black seed oil exerts its anti-inflammatory effect augmented with honey.
The US patent US7592327B2 allude that Nigella sativa purified formulation is beneficial for pulmonary sarcoidosis and several other ailments resembling pathologies with this disease. Based on this strong proof of concept, the recommended dosage is a half teaspoonful of black cumin oil with one teaspoon of honey regularly. The dosage may be increased up to one teaspoon depending on the patient's conditions.
Scientific studies provide essential information that anti-inflammatory and immunoregulatory components are in the oily part of the black seed oil. We recommend perfect press black seed oil one teaspoonful with an equal volume of tea or coffee based on this trustworthy information.
For getting better results, initially take ½ teaspoon of Nigella sativa with the same volume of honey in the first week, followed by the above-described dose. This treatment regimen has a logical background. Black seed oil exerts its anti-inflammatory effect augmented with honey.
References
1. Hossain A. The Effects of Nigella Sativa on the Immune Disorders. https://wwwauthoreacom/doi/full/1022541/au15887885661578558. 2020.
2. Majdalawieh AF, Fayyad MW. Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review. Int Immunopharmacol. 2015;28(1):295-304.
https://pubmed.ncbi.nlm.nih.gov/26117430/
3. May B. Managing Sarcoidosis During COVID-19 Pandemic: An Expert Guidance Statement. https://wwwpulmonologyadvisorcom/home/topics/lung-infection/managing-sarcoidosis-during-covid-19-pandemic-an-expert-guidance-statement/. 2020.
4. Shaterzadeh-Yazdi H, Noorbakhsh MF, Hayati F, Samarghandian S, Farkhondeh T. Immunomodulatory and Anti-inflammatory Effects of Thymoquinone. Cardiovasc Hematol Disord Drug Targets. 2018;18(1):52-60.
https://pubmed.ncbi.nlm.nih.gov/29437018/
5. Loke WS, Herbert C, Thomas PS. Sarcoidosis: Immunopathogenesis and Immunological Markers. Int J Chronic Dis. 2013;2013:928601.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590933/
6. US7592327B2. Asthma/allergy therapy that targets T-lymphocytes and/or eosinophils -. https://patentsgooglecom/patent/US7592327B2/en.
7. Boskabady MH, Vahedi N, Amery S, Khakzad MR. The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs. J Ethnopharmacol. 2011;137(2):1028-34.
https://pubmed.ncbi.nlm.nih.gov/21801826/
1. Hossain A. The Effects of Nigella Sativa on the Immune Disorders. https://wwwauthoreacom/doi/full/1022541/au15887885661578558. 2020.
2. Majdalawieh AF, Fayyad MW. Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review. Int Immunopharmacol. 2015;28(1):295-304.
https://pubmed.ncbi.nlm.nih.gov/26117430/
3. May B. Managing Sarcoidosis During COVID-19 Pandemic: An Expert Guidance Statement. https://wwwpulmonologyadvisorcom/home/topics/lung-infection/managing-sarcoidosis-during-covid-19-pandemic-an-expert-guidance-statement/. 2020.
4. Shaterzadeh-Yazdi H, Noorbakhsh MF, Hayati F, Samarghandian S, Farkhondeh T. Immunomodulatory and Anti-inflammatory Effects of Thymoquinone. Cardiovasc Hematol Disord Drug Targets. 2018;18(1):52-60.
https://pubmed.ncbi.nlm.nih.gov/29437018/
5. Loke WS, Herbert C, Thomas PS. Sarcoidosis: Immunopathogenesis and Immunological Markers. Int J Chronic Dis. 2013;2013:928601.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590933/
6. US7592327B2. Asthma/allergy therapy that targets T-lymphocytes and/or eosinophils -. https://patentsgooglecom/patent/US7592327B2/en.
7. Boskabady MH, Vahedi N, Amery S, Khakzad MR. The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs. J Ethnopharmacol. 2011;137(2):1028-34.
https://pubmed.ncbi.nlm.nih.gov/21801826/
